The schedule of the competition
| Stage | Draw date | First leg | Second leg |
|---|---|---|---|
| First stage | 20 December 2021[16] | 8–9 February 2022 | 15–16 February 2022 |
| Second stage | 22–24 February 2022 | 1–3 March 2022 | |
| Third stage | 8–10 March 2022 | 15–17 March 2022 | |
| Group stage | 23 March 2022 |
Matchday 1: 5–7 April 2022 Matchday 2: 12–14 April 2022 Matchday 3: 26–28 April 2022 Matchday 4: 3–5 May 2022 Matchday 5: 17–19 May 2022 Matchday 6: 24–26 May 2022 |
|
| Round of 16 | 1 June 2022 | 28–30 June 2022 | 5–7 July 2022 |
| Quarter-finals | 2–4 August 2022 | 9–11 August 2022 | |
| Semi-finals | 30 August – 1 September 2022 | 6–8 September 2022 | |
| Final | 29 October 2022 at Estadio Monumental Isidro Romero Carbo in Guayaquil | ||
