2022 CONCACAF Champions League Round of 16

Matches
16 February 2022
18:00 (17:00 UTC−6)
Guastatoya v León
22 February 2022
22:30 (21:30 UTC−6)
León v Guastatoya
17 February 2022
22:00 (21:00 UTC−6)
Motagua v Seattle Sounders
24 February 2022
22:30 (19:30 UTC−8)
Seattle Sounders v Motagua
Lumen Field, Seattle
17 February 2022
20:00 (19:00 UTC−6)
Comunicaciones v Colorado Rapids
23 February 2022
20:30 (18:30 UTC−7)
Colorado Rapids v Comunicaciones
DSG Park, Commerce City
15 February 2022
20:00 (19:00 UTC−6)
Santos de Guápiles v New York City FC
23 February 2022
18:00 (18:00 UTC−5)
New York City FC v Santos de Guápiles
Banc of California Stadium, Los Angeles, California[note 1]
16 February 2022
22:00 (21:00 UTC−6)
Saprissa v UNAM
23 February 2022
22:30 (21:30 UTC−6)
UNAM v Saprissa
15 February 2022
18:00 (18:00 UTC−5)
Cavaly v New England Revolution
Gillette Stadium, Foxborough
22 February 2022
18:00 (18:00 UTC−5)
New England Revolution v Cavaly
Gillette Stadium, Foxborough
15 February 2022
22:00 (21:00 UTC−6)
Santos Laguna v CF Montréal
22 February 2022
20:30 (20:30 UTC−5)
CF Montréal v Santos Laguna
16 February 2022
20:00 (20:00 UTC−5)
Forge FC v Cruz Azul
24 February 2022
20:30 (19:30 UTC−6)
Cruz Azul v Forge FC